Mercedes-Benz 2020 motor show set to impress in Letterkenny

first_imgCome and experience awesome this weekend at Connolly’s 2020 Mercedes-Benz Motor Show in Letterkenny. The exclusive event gives Mercedes fans a special opportunity to test drive the entire 2020 range along with a selected of Mercedes-Benz Certified Used Cars.The event takes place at Letterkenny Golf Club on Saturday 2nd November and Sunday 3rd November 2019. The Mercedes Benz fully electric EQC will be available for test drive plus the CLS AMG 53 on static display.What’s Happening? Mercedes-Benz Motor ShowWhere? Letterkenny Golf ClubWhen? Saturday & Sunday November 2nd& 3rdTime: 10am-4pm Saturday & 11am-4pm SundayTo prebook a test drive email: [email protected] or you can call into us any time on Saturday between the opening hours.View all the Connolly’s 2020 Mercedes-Benz stock at http://bit.ly/35OnPCd *Please note a full driver’s licence is require for test driving and must be presented on the day for insurance.Mercedes-Benz 2020 motor show set to impress in Letterkenny was last modified: October 22nd, 2019 by Rachel McLaughlinShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:Connolly’s SligoLetterkenny Golf clubMercedes-Benz Motor Showlast_img read more

Warriors: Who will start at center Saturday night against Lakers?

first_imgSAN FRANCISCO — As the Warriors deal with early injuries to the team’s top two centers, Omari Spellman is expected to start at center in the first preseason game against the Lakers on Saturday. Marquese Chriss will be the backup.“I believe those are our only two options,” Kerr said after practice Thursday.Rookie Eric Paschall could also get some run at the position.“We can throw Eric at 5. He’d be the shortest 5 in the history of the NBA,” Kerr said. “But the thing I love about Eric is his …last_img

Harnessing Cellular Machines for Humans

first_imgThe cell is loaded with molecular machines, so why reinvent the wheel?  or the whole truck?  Martin G. L. van den Heuvel and Cees Dekker wrote in Science that engineers ought to put the existing technology to work.1 The biological cell is equipped with a variety of molecular machines that perform complex mechanical tasks such as cell division or intracellular transport.  One can envision employing these biological motors in artificial environments.  We review the progress that has been made in using motor proteins for powering or manipulating nanoscale components.  In particular, kinesin and myosin biomotors that move along linear biofilaments have been widely explored as active components.  Currently realized applications are merely proof-of-principle demonstrations.  Yet, the sheer availability of an entire ready-to-use toolbox of nanosized biological motors is a great opportunity that calls for exploration.It’s time to put these ready and willing workhorses to work.  Their illustration shows diagrams of ATP synthase and a bacterial flagellum, kinesin, dynein, myosin and RNA polymerase.  Of the flagellum, they said, “This powerful motor, assembled from more than 20 different proteins, is driven by an inward proton flux that is converted by several torque-generating stators into a rotary motion of the cylindrical rings and central shaft.”    They reviewed the various motors and experiments to date to harness and control them.  Some day we might use cellular motors to sort, assemble, concentrate or manufacture materials on demand.  Or, we might try to copy them from scratch with our own building blocks.  But why do that?  “The small size and force-exerting capabilities of motor proteins and the range of opportunities for specific engineering give them unique advantages over current human-made motors,” they said.  The sky is the limit; the field seems limited only by our own imaginations.  “Upon studying and using biomotors, we will gather a lot of knowledge that is of interest to biology, material science, and chemistry, and it is reasonable to expect spin-offs for medicine, sensors, electronics, or engineering,” they concluded.  “The exploration of biomotors in technology will thus remain an interdisciplinary playground for many years to come.”    Oh, one other thing.  They did make a quick comment about where these machines came from.  Here is paragraph two of their article:A huge amount of biological research in recent decades has spurred the realization that the living cell can be viewed as a miniature factory that contains a large collection of dedicated protein machines (1)2.  Consider the complicated tasks that a single cell can perform: It can create a full copy of itself in less than an hour; it can proofread and repair errors in its own DNA, sense its environment and respond to it, change its shape and morphology, and obtain energy from photosynthesis or metabolism, using principles that are similar to solar cells or batteries.  All this functionality derives from thousands of sophisticated proteins, optimized by billions of years of evolution.  At the moment, we can only dream of constructing machines of similar size that possess just a fraction of the functionality of these natural wonders.While we’re on the subject, let’s look at a cellular device that recently got more praise: the cilium.  This little rod-like projection on most cells is doing more work than previously thought.  “Appreciation is now growing for primary cilia,” said Christenson and Ott in Science,3 primary cilia being “the nonmotile counterparts, present as a single copy on the surface of most cell types in our body.”    If primary cilia don’t beat and wave like the moving kind, what do they do?  Well, for one thing, “they function as unique antenna-like structures, probing the extracellular environment for molecules that are recognized by the receptors they bear.  This sensory function allows primary cilia to coordinate numerous intercellular signaling pathways that regulate growth, survival, and differentiation of cells during embryonic development and maintenance of healthy tissues.”  New research shows that a suite of molecules move in a coordinated fashion in and out of the cilium, creating a powerful switch by which cells can turn on and off a set of signaling pathways.  That’s pretty cool for an complex antenna previously thought to be nothing more than a little bitty hair on a tiny cell.41Martin G. L. van den Heuvel and Cees Dekker, “Motor Proteins at Work for Nanotechnology,” Nature 20 July 2007: Vol. 317. no. 5836, pp. 333-336, DOI: 10.1126/science.1139570.2This reference was to Bruce Alberts’ 1998 paper that made a similar statement, calling the study of molecular machines the “biology of the future” (see 01/09/2002).3Søren Tvorup Christensen and Carolyn Marie Ott, “Cell Signaling: A Ciliary Signaling Switch,” Science, 20 July 2007: Vol. 317. no. 5836, pp. 330-331, DOI: 10.1126/science.1146180.4The ones that move are way cool: see 12/19/2005, 03/12/2001.So, “thousands of sophisticated proteins, optimized by billions of years of evolution.”  Gimme a BREAK!(Visited 37 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Cape Town Stadium 1

first_imgLocation: Cape Town, Western Cape provinceCapacity: 68 000 seatsMatches: Uruguay vs France (11 June), Italy vs Paraguay (14 June), England vs Algeria (18 June), Portugal vs North Korea (21 June), Cameroon vs Netherlands (24 June), Round of 16 (29 June), Quarter-final (3 July), Semi-final (6 July)Click on a thumbnail for a low-resolution image, or right-click on the link below it to download a high-resolution copy of the image.  Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image Photo: Rodger Bosch, MediaClubSouthAfrica.com• Download high-resolution image {loadposition fifa}last_img read more

Soon-to-be dad Smith gets added inspiration to go home a champ

first_imgPhoto by Tristan Tamayo/INQUIRER.netAfter losing two straight games in the 2017 PBA Commissioner’s Cup Finals, TNT was in dire need of an inspiration.Little do they know that it would come all the way from Seattle, Washington, where Joshua Smith’s girlfriend is due to give birth within the next 24 hours.ADVERTISEMENT “The team know what I’m sacrificing outside of my foot, which is the birth of my daughter,” said the reinforcement.The KaTropa even went out of their way to commemorate the game to the Smiths, wearing a tape on the left side of their jersey bearing the name of Smith’s girlfriend Kristy.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSMalditas save PH from shutout“It’s a rallying point because Josh has been playing hurt and his girlfriend is giving birth,” said Racela.“If you are hurt, you could use that as an excuse to go home so that you’ll be there beside your girlfriend giving birth, but he chose to stay here and play in the Finals and work for the championship. We just want to honor Joshua and his girlfriend.”With his family on his mind, Smith delivered a performance to remember, dropping 20 points, 15 rebounds, and two assists to carry the KaTropa to a 102-97 Game 4 win over San Miguel and equalize the best-of-seven championship series to two games apiece. Cayetano to unmask people behind ‘smear campaign’ vs him, SEA Games Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games LATEST STORIES LOOK: Jane De Leon meets fellow ‘Darna’ Marian Rivera Don’t miss out on the latest news and information. Lacson: SEA Games fund put in foundation like ‘Napoles case’ Another vape smoker nabbed in Lucena What ‘missteps’? Pagasa: Kammuri now a typhoon, may enter PAR by weekend Pagasa: Kammuri now a typhoon, may enter PAR by weekend MOST READ Smith shared that tasting the victory has helped in alleviating his woes and is pushing him harder to come home to the Smith household with a championship to boot.“I’m feeling a lot better that we won, but I’ll try to get some rest and be ready for tomorrow,” he said. “The way I look at it, there’s two more games, with a chance to three, and I’ll have a chance to relax and be a dad after that. So I might as well give it all I can.”Sports Related Videospowered by AdSparcRead Next China furious as Trump signs bills in support of Hong Kong No fireworks, but Pacquiao, Horn promise a good bout for fans View commentslast_img read more

LOOK: Paul Millsap bids farewell to Atlanta on Instagram

first_imgSports Related Videospowered by AdSparcRead Next WBO says it will re-score Pacquiao-Horn fight; result stands MOST READ Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Don’t miss out on the latest news and information. China furious as Trump signs bills in support of Hong Kong LATEST STORIES Nikki Valdez rushes self to ER due to respiratory tract infection “Tried to find the words to better help explain how much the fans and the city of Atlanta has meant to me but words can not explain it,” Millsap wrote, along with a photo of himself in a Hawks uniform.“From an average Joe to a 4 time All ⭐️(star) Atlanta I could not have done it without you.”“Thank you for an amazing 4 years! Thank you for embrace me and my family and for always having my back. I will always hold a special place in my heart for you,” he added, with the hashtags #truetoatlanta #anchormanout #untilnexttime.Since transferring to Atlanta from the Utah Jazz in 2013, Millsap had anchored the team down low with his versatility on both ends of the floor.Although considered undersized at the power forward position, the 6’8 forward has averaged solid numbers of 17.4 points, 8.3 rebounds and 3.3 assists per game during his tenure in Atlanta.  Khristian Ibarrola /raADVERTISEMENT LOOK: Jane De Leon meets fellow ‘Darna’ Marian Riveracenter_img Lacson: SEA Games fund put in foundation like ‘Napoles case’ Another vape smoker nabbed in Lucena Ever the consummate professional, the 32-year-old forward recently penned a heartfelt goodbye to the entire city of Atlanta and paid homage to its loyal fans. Pagasa: Kammuri now a typhoon, may enter PAR by weekend View comments After his fruitful four seasons with the Atlanta Hawks, Paul Millsap is headed West to join Nikola Jokic and the rest of the Denver Nuggets.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsThe four-time All-Star recently signed a reported three-year, $90-million contract with the “Mile High City,” in exchange for Jamal Crawford, Diamond Stone and the Los Angeles Clippers’ 2018 first-round draft pick.ADVERTISEMENT Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Pagasa: Kammuri now a typhoon, may enter PAR by weekendlast_img read more

Pak Army chief Raheel Sharif warns Nawaz Sharif against use of force but PM defiant

first_imgPakistani protesters help carry their injured colleague to an ambulance during a clashes near prime minister’s home in Islamabad, Pakistan on Sunday, Aug. 31, 2014. Photo: APAn earthquake registering six on the Richter Scale rumbled through the northern half of Pakistan on Sunday, fading away into Kashmir to the east and Khyber Pakhtunkhwa to the west. But no-one really noticed, because the republic’s latest tryst with democracy was being teargassed and lathicharged in the heart of Islamabad, the Prime Minister was in a corner, and the Army was looking restive again.Talk of a military coup hung in the air as the Army’s top brass advanced a high-level meeting by a day and met at its Rawalpindi headquarters. The meeting, presided over by Army chief General Raheel Sharif, lasted four hours and delivered a loaded warning to Sharif, saying the situation should be “resolved politically without wasting any time and without recourse to violent means,” ominously adding that the Army “remains committed to playing its part in ensuring security of the state and will never fall short of meeting national aspirations”. Sharif’s office came out a statement of its own, saying that the interior ministry has been “directed to utilise all resources to ensure protection of state institutions without loss of life”, and calling a joint session of Parliament on Tuesday.   Pakistan PM Nawaz SharifThe Army meet came after large-scale violence in Islamabad’s Red Zone that began late on Saturday claimed the lives of three protesters, including a woman, in clashes between security forces and protesters who have besieged the area for 18 days now. The Red Zone houses Pakistan’s Parliament as well as the Presidency, Supreme Court, and Prime Minister’s official residence and has been the site of a massive sit-in protest seeking Sharif’s resignation, and featuring a convergence of supporters of Pakistan Tehrik-e-Insaf (PTI) leader Imran Khan and Pakistan Awami Tehrik (PAT) leader Tahir-ul-Qadri.Sharif’s political foes weren’t about to quit either. Khan asked all Pakistanis to join him in the protest. “I request all the nation, civil servants, bureaucrats and police to rebel against this illegal government,” he told his supporters, asking officials to “ignore all illegal orders” from the government. “I am prepared to die fighting for the freedom for my people, he said, declaring: “Allah, ya azaadi ya maut (freedom or death).” Echoing Khan’s ultimatum asking Sharif to step down in 24 hours, Qadri said he would “sacrifice” himself.advertisementPakistan Army chief General Raheel Sharif. Photo: APSpeaking to Mail Today late on Sunday, Imran Khan made it clear that his party will only resume talks if Sharif resigns. “We will keep on protesting until Nawaz Sharif resigns. I will stand firm even if all of my team and supporters deceive me,” Khan said.Another source told Mail Today that the Army’s quick response force known as ‘Triple One Brigade’ has already reached Islamabad and is in touch with the high command.  This particular brigade has been a key player in previous coups.The rioting began late on Saturday as thousands of Qadri and Khan supporters attempted to storm the prime minister’s residence, and later the Parliament building. The police fired rubber bullets and teargas shells to disperse the violent protesters. Pakistan’s electronic media reported 17 people killed and 500 wounded but doctors confirmed only three dead and 200 injured. “Three people have been killed while more than two hundred were injured,” a spokesperson of Pakistan Institute of Medical Sciences told Mail Today.As Sunday dawned, the heart of Islamabad looked like a battleground even as sporadic clashes continued. This correspondent witnessed scores of women and children running helter-skelter as policemen fired at will. Many were injured and rushed to hospitals where most were pronounced as critically injured. “They fired teargas shells at us. I witnessed a dozen women falling down after being hit by bullets,” said Ehsanullah, a die-hard supporter of cleric Qadri. Ehsanullah himself received a bullet in leg, and was bleeding profusely.Tahir-ul-Qadri addresses his supporters during an on-going protest near the parliament building in Islamabad, Pakistan, Saturday, Aug 30, 2014. Photo: APDefence Minister Khwaja Asif said the police action was in self-defence. “Law enforcement agencies were left with no option other than using force to keep protesters away. Sadly it was the protesters who challenged the government’s writ. The police only retaliated,” Asif told Mail Today. Prime Minister Sharif had rushed to Islamabad by noon from his residence in Raiwind near Lahore and held an hour-long meeting with his Cabinet.Insiders told Mail Today that Prime Minister advised his team, comprising Information Minister Pervez Rashid, Minister for Planning Ahsan Iqbal, Finance Minister Ishaq Dar and Defence Minister Asif to invite Imran Khan and Qadri for negotiations. “The government has decided to invite Imran Khan and Tahir-ul-Qadri to come across the table for talks. We are waiting for their response,” Rashid told Mail Today.advertisementMeanwhile, in another blow to Imran Khan, PTI president Javed Hashmi broke ranks to criticise his leader for urging a forced entry into the prime minister’s residence. Hashmi made it clear that the former Pakistan cricket captain Khan would be responsible if Army conduct another coup. “Imran Khan will be responsible if Army takes over,” Hashmi told reporters at a press conference. Imran Khan reacted with fury, expelling Hashmi immediately.last_img read more